王宇浩实验室
王宇浩
研究员,博士生导师
研究领域:
1.肠道微生物参与调控宿主代谢和免疫的分子机制
2.益生菌及其代谢产物的筛选和应用
3.肠道内环境稳态
王宇浩

代表性论著

1. Y. Wang*, M. Wang, J. Chen, Y. Li, Z. Kuang, C. Dende, P. Raj, G. Quinn, Z. Hu, T. Srinivasan, B. Hassell, K. A. Ruhn, C. L. Behrendt, T. Liang, X. Dou, Z. Song, L. V. Hooper*. The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9. Science. 381, 851-857 (2023). *Corresponding author

2. Y. Wang, Z. Kuang, X. Yu, K. A. Ruhn, M. Kubo and L. V. Hooper. The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. Science. 357, 912-916 (2017).

3. Y. Wang and L. V. Hooper. Immune control of the microbiota prevents obesity. Science. 365, 316-317 (2019).

4. X. Yu*, Y. Wang*, M. Deng, Y. Li, K. A. Ruhn, C. Zhang, L. V. Hooper. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. Elife. 3, e04406 (2014). *Contributed equally.

5. Z. Kuang, Y. Wang, Y. Li, C. Ye, K. A. Ruhn, C. L. Behrendt, E. N. Olson, L. V. Hooper. The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3. Science. 365, 1428-1434 (2019).

6. S. Bel, M. Pendse, Y. Wang, K. A. Ruhn, B. Hassell, T. Leal, S. E. Winter, and L. V. Hooper. Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine. Science. 357, 1047-1052 (2017).

 7. Z. Hu, C. Zhang, L. Sifuentes-Dominguez, C. M. Zarek, D. C. Propheter, Z. Kuang, Y. Wang, M. Pendse, K. A. Ruhn, B. Hassell, C. L. Behrendt, B. Zhang, P. Raj, T. A. Harris-Tryon, T. A. Reese, L. V. Hooper. Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection. Science. 374, eabe6723 (2021).

8. S. Gattu, Y. Bang, M. Pendse, C. Dende, A. L. Chara, T. A. Harris, Y. Wang, K. A. Ruhn, Z. Kuang, S. Sockanathan, and L. V. Hooper. Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity. PNAS. 116, 10911-10916 (2019).

 

 


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