Publications directly from the Sun Lab since 2018:
1） Wu, D., and Sun, Y.: The functional redundancy of neddylation E2s and E3s in modulating the fitness of regulatory T cells. Research, Aug 03, 2023. https://spj.science.org/doi/abs/10.34133/research.0212.
2）Mao, H, Lin, X., and Sun, Y.: Neddylation regulation of immune responses. Research 2023;6:Article 0283. https://doi.org/10.34133/ research.0283
3）Zhang, S., You, X., Zheng, Y., Sheng, Y., Xiong, X., and Sun, Y.: The UBE2C/CDH1/DEPTOR axis is an oncogene-tumor suppressor cascade in lung cancer cells. J Clin Invest. 2023 Feb 15;133(4):e162434. doi: 10.1172/JCI162434.
4）Xu, T., Ma, Q., Li, Y., Yu, Q., Pan, P., Zheng, Y., Li, Z., Xiong, X., Hou, T., Yu, B., Liu, H., and Sun., Y.: A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer. Signal Transduction Targeted Ther. 2022 Oct 17;7(1):354. doi: 10.1038/s41392-022-01182-w. 7:4208-4222, 2022.
5）Tan, M., Chang, Y., Li, H., Tang, Z., Nyati, M., and Sun, Y.: The Sag/Rbx2-Shoc2 axis regulates the conversion of mPanINs to neoplastic cystic lesions in the Kras pancreatic tumor model. Cell Reports, 2022 Dec 20;41(12):111837. doi: 10.1016/j.celrep.2022.111837.
6）Wu, D., Li, H., Liu, M., Qin, J. and Sun, Y.: Ube2m-Rbx1 neddylation-Cullin Ring E3 Ligases is essential for the maintenance of Regulatory T cell fitness. Nature Communs. 2022, May 31, 13:3021 https://doi.org/10.1038/s41467-022-30707-8
7）Zhou, Q., Lin, W., Wang, C., Sun, F., Ju, S., Wang, Y., Chen, Y., Chen, Q., Li, H., Wang, L., Hu, Z., Jin, H., Wang, X., and Sun, Y.: Neddylation inhibition induces glutamine uptake and by targeting CRL3SPOP E3 ligase in cancer cells. Nature Communs. 2022, May 31, 13:3034 https://doi.org/10.1038/s41467-022-30559-2
8）Li, Y., Wang, C., Xu, T., Pan, P., Yu, Q., Xu, L., Xiong, X., Hou, T., Cui, S*., and Sun, Y.*: Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy. Acta Pharm Sin B. 11: 3567-3584, 2021 https://doi.org/10.1016/j.apsb.2021.07.012.
9）Zhao, Y.*, Xiong, X., and Sun, Y.*: Cullin-RING Ligase 5: Functional characterization and its role in human cancers. Sem. Cancer Biol. 67:61-79, 2020. S1044-579X(20)30085-7. doi: https://doi.org/10.1016/j.semcancer.2020.04.003.
10） Zhang, S., Shen, Y., Li, H., Bi, C., Sun, Y., Xiong, X., Wei, W., and Sun, Y.: The negative cross-talk between SAG and APC/C E3s in regulation of cell cycle and drug resistance. Cell Reports. 32, 108102, Sept. 8, 2020， https://doi.org/10.1016/j.celrep.2020.108102
11） Zhang, S., Xiong, X., and Sun, Y.: Functional characterization of SOX2 as an anticancer target. Signal Transduction Targeted Ther. 2020 Jul 29;5(1):135. doi: 10.1038/s41392-020-00242-3.
12） Yin, Y., Xie, C., Li, H., Tan, M., Chen, G., Schiff, R., Xiong, X., and Sun, Y.: The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proc. Natl. Acad Sci USA. 116:20528-20538, 2019. Oct 8. doi: 10.1073/pnas.1905973116. PMID 31548378.
13） Lan, H., Tan, M., Zhang, Q., Li, H., Xiong, X. and Sun, Y.: LSD1 destabilizes FBXW7 and inhibits FBXW7 activity independent of its demethylase activity. Proc Natl Acad Sci USA 116: 12311-12320, 2019. PMID: 31152129. PMCID: PMC6589684. 2019 May 31. pii: 201902012. doi: 10.1073/pnas.1902012116.
14） Xie, C., Tan, M., Lin, X., Wu, D., Jiang, Y., Tan, Y., Li, H., Ma, Y., Xiong, X., and Sun, Y.: The FBXW7-SHOC2-Raptor axis controls the cross-talks between the RAS/ERK and mTORC1 signaling pathways. Cell Reports. 2019 Mar 12; 26(11):3037-3050.e4. doi: 10.1016/j.celrep.2019.02.052.
15） Yang, F., Xu, J., Li, H., Tan, M., Xiong, X., and Sun, Y.: FBXW2 suppresses migration and invasion of lung cancer cells via promoting ubiquitylation and degradation of β-catenin. Nat. Communs, 2019 March 27, 10:1382 | https://doi.org/10.1038/s41467-019-09289-5.
16）Mao, H., Tang, Z., Li, H., Sun, B., Tan, M., Fan, S., Zhu, Y., and Sun, Y.: Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1. Protein & Cell. 2019 March 9, doi: 10.1007/s13238-019-0614-3.
17） Zhou, Q., Li, H., Li, Y., Tan, M., Fan, S., Cao, C., Meng, F., Zhu, L., Zhao, L., Guan, M.-X., Jin, H., and Sun, Y.: Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. JCI Insight. 2019 Jan 22. pii: 121582. doi: 10.1172/jci.insight.121582.
18） Zhou, W., Xu, J., Tan, M., Zhang, J., Li, H., Li, H., Wei, W., Sun, Y.: UBE2M is a stress-inducible dual E2 for neddylation and ubiquitylation that promotes targeted degradation of UBE2F. Mol Cell 70: 1008–1024, 2018.
